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Exophthalmos (bulging eyes)
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Exophthalmos, also known as proptosis, is the medical term for bulging or protruding eyeballs. It can affect 1 or both eyes and is most often caused by thyroid eye disease.
If you have exophthalmos, there is a small risk of your optic nerve (which sends signals between your eye and brain) becoming compressed, which may affect your sight permanently if it is not treated quickly.
Many of the symptoms of thyroid eye disease tend to improve over time, although this can take several years. There's a chance your eyes will continue to protrude if corrective surgery is not done.
Some people with exophthalmos are left with long-term vision problems, such as double vision. However, permanent loss of vision is rare if the condition is diagnosed and treated quickly.
When to get medical advice
See a GP or an optician if you notice that 1 or both of your eyes are protruding.
It's important to identify the cause, as treatment is often more effective if it's started as soon as possible.
If necessary, a GP or optician can refer you to an eye specialist (ophthalmologist) for further assessment.
If you're referred to an eye specialist (ophthalmologist), they may:
- check how well you're able to move your eyes
- use an instrument called an exophthalmometer to measure how far your eyeball protrudes
- arrange for a CT scan or MRI scan
- arrange for a blood test to check how well your thyroid gland is working
You may be referred to a doctor who specialise in conditions affecting glands and hormones (endocrinologist) if your thyroid hormone levels are found to be abnormal.
Causes of exophthalmos
One of the main causes of exophthalmos in the UK is thyroid eye disease, also known as Graves' ophthalmopathy disease.
Graves' ophthalmopathy disease affects around 1 in every 3 people with an overactive thyroid gland (hyperthyroidism) caused by Graves' disease. It's more common in women and people who smoke.
Graves' disease is an autoimmune condition, which is where the immune system mistakenly attacks healthy tissue.
In the case of thyroid eye disease, the immune system attacks the muscles and fatty tissues around and behind the eye, making them swollen.
Thyroid eye disease can also occasionally affect people with an underactive thyroid gland (hypothyroidism) and, in rare cases, people with normal thyroid function.
Exophthalmos can also have other causes, but these are generally less common.
Other causes of exophthalmos can include:
- an injury to the eyes
- bleeding behind the eyes
- abnormally shaped blood vessels behind the eyes
- an infection of the tissue in the eye socket
- cancerous tumours, such as those caused by neuroblastoma and some soft tissue sarcomas
Rarely, exophthalmos can also affect newborn babies.
If exophthalmos is caused by thyroid eye disease, the following treatments are often helpful:
- medicine to correct the level of thyroid hormones in your blood. This will not necessarily improve the problems with your eyes, but may stop them getting worse
- steroid injections into a vein (intravenously) – this can help reduce the inflammation associated with the condition
- corrective surgery – this may be done to improve the appearance of your eyes once the inflammation is under control
Other useful treatments include using eye drops to reduce eye dryness and irritation, and wearing special lenses to correct double vision. Stopping smoking can also help.
In other cases, treatment will vary depending on the cause. For example, radiotherapy, chemotherapy and/or surgery may be recommended if exophthalmos is caused by a tumour.
Find out more about treating exophthalmos.
Complications of exophthalmos
Depending on what's causing your bulging eyes, you may also have other associated symptoms. For example, if exophthalmos is caused by a thyroid eye disease, your eyes may also be:
- inflamed, red and painful
- dry and "gritty"
- sensitive to light (photophobia)
You may also experience some double vision.
If you have severe exophthalmos, you may not be able to close your eyes properly. This can damage the transparent tissue that covers the front of your eyes (corneas) by causing them to dry out.
If your corneas become very dry, an infection or ulcers may develop. These could damage your vision if left untreated.